Natural OCD Supplement

headSTRONG OCDEFENSE™ has been scientifically formulated to alleviate your OCD, using the latest advances in the fields of nutrition, neuroscience, and psychology. Active compounds in the headSTRONG OCDEFENSE™ formula are backed by clinical research and have been cited in over 60 OCD-related scientific studies. Just one of the active components alone significantly improved OCD symptoms with 42% of participants reporting "much" or "very much improved" after 12 weeks of treatment compared to a placebo.

headSTRONG OCDEFENSE™ will help you…   

Overcome feelings of doubt, incompleteness, anxiety, and fear.

Control your symptoms until they disappear.

Defeat your OCD for good!

headSTRONG OCDEFENSE™ targets the major neurotransmitters involved in OCD, including serotonin, taurine, and GABA. Combining ingredients that work synergistically to naturally balance your brain's neurotransmitters, headSTRONG OCDEFENSE™ provides the biochemical basis that will allow you to Overcome, Control, and Defeat your OCD.

Top research and over 14 years of manufacturing experience have combined to create the first and only OCD-specific formula. The patent-pending complex in headSTRONG OCDEFENSE™ includes a specialized and clinically-tested proprietary blend of:


Inositol regulates numerous cellular functions, helping to maintain proper electrical energy and nutrient transfer across cell membranes, thus facilitating nerve impulses. It also acts as a lipotropic, converting fats into other useful products. Inositol has demonstrated efficacy in several studies as a natural OCD treatment. In a recent study, following 12 weeks of treatment with inositol supplements, OCD subjects showed deactivation in brain activity associated with OCD. Significant reductions in OCD severity scores also followed treatment.

Clinical trials have been positive when compared to the use of fluvoxamine (Luvox), a serotonin re-uptake inhibitor drug that is typically prescribed to treat OCD.

Hypericin (Hypericum perforatum extract)

Hypericin is an extract from St. John's Wort (Hypericum perforatum), a naturally occurring flowering plant that historically has been used to manage the symptoms related to many mental disorders. It works by increasing the amount of serotonin available in the brain, acting much like the leading prescription medications used for OCD. In fact, several studies show that Hypericum is just as effective for OCD as low doses of fluoxetine (Prozac), a leading prescription medicine often prescribed for OCD.

A recent open-label study found that the OCD symptoms of patients taking Hypericum extracts significantly improved compared to placebo, with 42% "much" or "very much improved" after 12 weeks of treatment.

Hypericum also affects the release of the stress hormone cortisol and helps protect the brain from the high levels of cortisol usually present in OCD patients.

Low incidence of side effects

A recent review of St Johns wort suggests that it has a lower incidence of side effects than prescription antidepressants. More common side effects include, headache, fatigue, and increased sensitivity to sunlight. (See FAQ)

Valerian Root (Valeriana Officinalis)

Taken from a small plant that thrives throughout most of the world, valerian root has been shown scientifically to have an effect on the gamma-aminobutyric acid (GABA) system in the brain, which is known as a contributing factor to OCD. Many clinical research studies have shown that Valerian root relieves the symptoms of anxiety and OCD in the majority of cases. Treating OCD with supplements like Valerian root can reduce the severity of symptoms by reducing the anxiety that arises from recurring intrusive thoughts.

Passion Flower (Passiflora incarnata)

Passiflora incarnata belongs to a group of plants classified as "serotonin-derived" by their chemical composition. Clinical studies have indicated that the chemical components found in passion flower are effective at regulating the uptake of serotonin (5-HT) in the brain, lessening OCD symptoms.

Vitamin B6

Vitamin B6 has modulatory effects on both GABA and serotonin which are both involved in OCD. Furthermore, in a high-dose regimen this vitamin also blocks corticosteroid (e.g. cortisol) effects. Cortisol is a stress hormone and B vitamins, especially B6, reduce its effects. The regulation of hormones involved in stress regulation is useful in treating OCD. Vitamin B6 provides nutritional support for mood-related pathways and assists in allowing your brain to produce SAM-e, crucial to maintaining proper levels of the neurotransmitters serotonin, dopamine and norepinephrine.


Studies suggest that anxiety may be due in part to a reduction in magnesium levels; hence, treating OCD patients with magnesium is often effective. A number of OCD patients have reported a drastic improvement after increasing their magnesium intake. Magnesium deficiencies have also been linked to poor calcium absorption, irritability and mental disorders.


It has been proposed that OCD is the result of an imbalance of neurotransmitters in the brain. Neurotransmitters are chemicals that transfer signals between nerve cells. Calcium regulates neurotransmitter release, and calcium deficiencies can disrupt the transfer of nerve cell signals. Calcium also supports the increased activation of GABA. In addition, studies showed that blocking the release of calcium into the body exacerbates OCD symptoms whereas supplementation with calcium improves symptoms.

Hops Extract

Hops extract acts on the brain in the same way as benzodiazepine medications (psychoactive drugs that have hypnotic, sedative, anti-anxiety, amnesic and muscle relaxant properties). Hops may also help the body re-establish proper neurotransmitter release to improve the transfer of nerve cell signals, which can help with OCD. Well tolerated and well studied, hops extract specifically stimulates the GABA system to help with one of the proposed causes of OCD.

Perhaps you've been diagnosed with OCD and you'd like to try a natural treatment. Or, perhaps you've been suffering from the symptoms of OCD for years without a diagnosis. Either way, headSTRONG OCDEFENSE™ will help you reclaim your life.

Safety and quality

All ingredients used meet or exceed the requirements for the vitamin and nutraceutical industry as upheld by the U.S. Food and Drug Administration (FDA), the U.S. Pharmacopoeia (USP) and the Natural Products Association (NPA) current Good Manufacturing Practices (cGMP). The laboratory holds a Drug Manufacturing License issued by the Food and Drug Branch of the New York Department of Health Services, ensuring that the facility adheres to the quality-control standards required to manufacture prescription and over-the-counter pharmaceutical medications. Click here to read more on product safety.


Kobak KA, Taylor LV, Bystritsky A, et al. St John's wort versus placebo in obsessive compulsive disorder: results from a double-blind study. International Clinical Psychopharmacology. 2005;20:299-304.
Cauffield JS, Forbes HJ. Dietary supplements used in the treatment of depression, anxiety, and sleep disorders. Lippincotts Prim Care Pract. 1999 May-Jun;3(3):290-304.
Fava M, Alpert J, Nierenberg AA, et al. A Double-blind, randomized trial of St John's wort, fluoxetine, and placebo in major depressive disorder. Journal of Clinical Psychopharmacology. 2005;25:441-447.
Linde K, Ramirez G, Mulrow CD, Pauls A, Weidenhammer W, Melchart D. St John's wort for depression–an overview and meta-analysis of randomised clinical trials. BMJ. 1996;313:253-258.
Taylor LH, Kobak KA. An open-label trial of St. John's Wort (Hypericum perforatum) in obsessive-compulsive disorder. The Journal of Clinical Psychiatry. 2000;61:575-578.

Monograph. Valeriana officinalis. Alternative Medicine Review. 2004;9:438-441. Andreatini R, Sartori VA, Seabra ML, Leite JR. Effect of valepotriates (valerian extract) in generalized anxiety disorder: a randomized placebo-controlled pilot study. Phytotherapy Research. 2002;16:650-654.
Bourin M, Bougerol T, Guitton B, Broutin E. A combination of plant extracts in the treatment of outpatients with adjustment disorder with anxious mood: controlled study versus placebo. Fundamental and Clinical Pharmacology. 1997;11(2):127-132.
Cropley M, Cave Z, Ellis J, Middleton RW. Effect of kava and valerian on human physiological and psychological responses to mental stress assessed under laboratory conditions. Phytotherapy Research. 2002;16:23-27.
Delsignore R, Orlando S, Costi D, Baroni MC, Butturini U. Clinical comparative evaluation of a stabilized valeriana extract and placebo. A Folha Medica. 1992;104(5):191-196.
Hadley S, Petry JJ. Valerian. American Family Physician. 2003;67:1755-1758.
Hattesohl M, Feistel B, Sievers H, Lehnfeld R, Hegger M, Winterhoff H. Extracts of Valeriana officinalis L. s.l. show anxiolytic and antidepressant effects but neither sedative nor myorelaxant properties. Phytomedicine. 2008 Jan;15(1-2):2-15.
Kohnen R, Oswald WD. The effects of valerian, propranolol, and their combination on activation, performance, and mood of healthy volunteers under social stress conditions. Pharmacopsychiatry. 1988;21:447-448.
Müller, D., Pfeil T, von den Driesch V. Treating depression comorbid with anxiety – results of an open, practice-oriented study with St John's wort WS® 5572 and valerian extract in high doses. Phytomedicine. 2003;10(Suppl 4):25-30.
Müller SF, Klement S. A combination of valerian and lemon balm is effective in the treatment of restlessness and dyssomnia in children. Phytomedicine. 2006 Jun;13(6):383-387.

Vitamin B6

Baldewicz T, Goodkin K, Feaster DJ, Blaney NT, Kumar M, Kumar A, Shor-Posner G, Baum M. Plasma pyridoxine deficiency is related to increased psychological distress in recently bereaved homosexual men. Psychosom Med. 1998 May-Jun;60(3):297-308.
Bell IR, Edman JS, Morrow FD, Marby DW, Mirages S, Perrone G, Kayne HL, Cole JO. B complex vitamin patterns in geriatric and young adult in patients with major depression. J Am Geriatr Soc. 1991 Mar;39(3):252-257.
Bermond P. Therapy of side effects of oral contraceptive agents with vitamin B6. Acta Vitaminol Enzymol. 1982;4(1-2):45-54.
De Souza MC, Walker AF, Robinson PA, Bolland K. A synergistic effect of a daily supplement for 1 month of 200 mg magnesium plus 50 mg vitamin B6 for the relief of anxiety-related premenstrual symptoms: a randomized, double-blind, crossover study. J Women's Health Gend Based Med. 2000 Mar;9(2):131-139.
Frazer CJ, Christensen H, Griffiths KM. Effectiveness of treatments for depression in older people. Med J Aust. 2005 Jun 20;182(12):627-632.
Kalinin VV, Zheleznova EV, Rogacheva TA, Sokolova LV, Polianskii DA, Zemlianaia AA, Nazmetdinova DM. A use of Magne-B6 in the treatment of anxiety-depressive states in patients with epilepsy. Zh Nevrol Psikhiatr Im S S Korsakova. 2004;104(8):51-55.
Kaplan BJ, Simpson JS, Ferre RC, Gorman CP, McMullen DM, Crawford SG. Effective mood stabilization with a chelated mineral supplement: an open-label trial in bipolar disorder. J Clin Psychiatry. 2001 Dec;62(12):936-944.
McCarty MF. High-dose pyridoxine as an 'anti-stress' strategy. Med Hypotheses. 2000 May;54(5):803-807.

Passion Flower

Akhondzadeh S, Naghavi HR, Vazirian M, Shayeganpour A, Rashidi H, Khani M. Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam. Journal of Clinical Pharmacy and Therapeutics. 2002;26(5):363-367.
Barbosa PR, Valvassori SS, Bordignon CL Jr, Kappel VD, Martins MR, Gavioli EC, Quevedo J, Reginatto FH. The aqueous extracts of Passiflora alata and Passiflora edulis reduce anxiety-related behaviors without affecting memory process in rats. Journal of Medicinal Food. 2008;11(2):282-288.
Bourin M, Bougerol T, Guitton B, Broutin E. A combination of plant extracts in the treatment of outpatients with adjustment disorder with anxious mood: controlled study versus placebo. Fundamental & Clinical Pharmacology. 1997;11(2):127-132.
Brown E, Hurd NS, McCall S, Ceremuga TE. Evaluation of the anxiolytic effects of chrysin, a Passiflora incarnata extract, in the laboratory rat. American Association of Nurse Anesthetists Journal. 2007;75(5):333-337.
Dhawan K, Dhawan S, Chhabra S. Attenuation of benzodiazepine dependence in mice by a tri-substituted benzoflavone moiety of Passiflora incarnata Linneaus: a non-habit forming anxiolytic. Journal of Pharmacy and Pharmaceutical Sciences. 2003;6(2):215-222.
Dhawan K, Kumar S, Sharma A. Anxiolytic activity of aerial and underground parts of Passiflora incarnata. Fitoterapia. 2001;72(8):922-926.
Dhawan K, Kumar S, Sharma A. Anti-anxiety studies on extracts of Passiflora incarnata Linneaus. Journal of Ethnopharmacology. 2001;78(2-3):165-170.
Ernst E. Herbal remedies for anxiety – a systematic review of controlled clinical trials. Phytomedicine. 2006;13(3):205-208.
Grundmann O, Wang J, McGregor GP, Butterweck V. Anxiolytic activity of a phytochemically characterized Passiflora incarnata extract is mediated via the GABAergic system. Planta Medica. 2008;74:1769-1773.
Krenn L. Passion Flower (Passiflora incarnata L.)–a reliable herbal sedative. Wien Med Wochenschr. 2002;152(15-16):404-6.
Miyasaka LS, Atallah AN, Soares BG. Passiflora for anxiety disorder. Cochrane Database Systematic Reviews. 2007;(1):CD004518.
Mori A, Hasegawa K, Murasaki M, Yamauchi T, et al.Clinical Evaluation of Passiflamin (passiflora extract) on neurosis – multicenter double blind study in comparison with mexazolam. Clinical Evaluation. 1993;21:383-440.
Movafegh A, Alizadeh R, Hajimohamadi F, Esfehani F, Nejatfar M. Preoperative oral Passiflora incarnata reduces anxiety in ambulatory surgery patients: a double-blind, placebo-controlled study. Anesthesia and Analgesia. 2008;106(6):1728-1732.
Park, J. Serotomide and safflomide modulate forskolin-stimulated cAMP formation via 5-HT1 receptor. Phytomedicine. 2008;15(12):1093-1098.


De Souza MC, Walker AF, Robinson PA, Bolland K. A synergistic effect of a daily supplement for 1 month of 200 mg magnesium plus 50 mg vitamin B6 for the relief of anxiety-related premenstrual symptoms: a randomized, double-blind, crossover study. Journal of Women's Health and Gender Based Medicine. 2000;9(2):131-139.
Grases G, Pérez-Castelló JA, Sanchis P, Casero A, Perelló J, Isern B, Rigo E, Grases F. Anxiety and stress among science students. Study of calcium and magnesium alterations. Magnesium Research. 2006;19(2):102-106.
Fromm L, Heath DL, Vink R, Nimmo AJ. Magnesium attenuates post-traumatic depression/anxiety following diffuse traumatic brain injury in rats. Journal of the American College of Nutrition. 2004;23(5):529S-533S.
Hanus M, Lafon J, Mathieu M. Double-blind, randomised, placebo-controlled study to evaluate the efficacy and safety of a fixed combination containing two plant extracts (Crataegus oxyacantha and Eschscholtzia californica) and magnesium in mild-to-moderate anxiety disorders. Current Medical Research and Opinion. 2004;20(1):63-71.
Jacka FN, Overland S, Stewart R, Tell GS, Bjelland I, Mykletun A. Association between magnesium intake and depression and anxiety in community-dwelling adults: the Hordaland Health Study. Australian and New Zealand Journal of Psychiatry. 2009;43(1):45-52.
Poleszak E, Szewczyk B, Kedzierska E, Wla P, Pilc A, Nowak G. Antidepressant- and anxiolytic-like activity of magnesium in mice. Pharmacology Biochemistry and Behavior. 2004;78(1):7-12.
Recarte García Andrade C, del Castillo Rueda A, Torres Segovia F. Anxiolytic effect of magnesium. Anales de Medicina Interna. 1991;8(11):576.
Seelig MS. Consequences of magnesium deficiency on the enhancement of stress reactions; preventive and therapeutic implications (a review). Journal of the American College of Nutrition. 1994;13(5):429-446.
Spasov AA, Iezhitsa IN, Kharitonova MV, Kravchenko MS. Depression-like and anxiety-related behaviour of rats fed with magnesium-deficient diet. Zh Vyssh Nerv Deiat Im I P Pavlova. 2008;58(4):476-485.


Oken RJ. Obsessive-compulsive disorder: cerebral calcium deficiency as a possible etiologic/pathogenetic factor–a case study. Med Hypotheses. 1997;49(6):513-514.
Egashira N, Okuno R, Abe M, Matsushita M, Mishima K, Iwasaki K, Oishi R, Nishimura R, Matsumoto Y, Fujiwara M. Calcium-channel antagonists inhibit marble-burying behavior in mice. J Pharmacol Sci. 2008;108(1):140-143.

Fux M, Benjamin J, Belmaker RH. Inositol versus placebo augmentation of serotonin reuptake inhibitors in the treatment of obsessive-compulsive disorder: a double-blind cross-over study. Int J Neuropsychopharmacol 1999;2:193-5.
Carey P. D, Warwick J, Harvey H, Stein D. J, Seedat S, Single photon emission computed tomography (SPECT) in obsessive-compulsive disorder before and after treatment with inositol.
Fux M, Levine J, Aviv A, Belmaker RH. Inositol treatment of obsessive-compulsive disorder. Am J Psychiatry 1996;153:1219-21.
Einat H, Belmaker RH. The effects of inositol treatment in animal models of psychiatric disorders. Journal of Affective Disorders. 2001;62:113-121.
Levine J. Controlled trials of inositol in psychiatry. European Neuropsychopharmacology. 1997;7:147-155.
Palatnik A, Frolov K, Fux M, Benjamin J. Double-blind, controlled, crossover trial of inositol versus fluvoxamine for the treatment of panic disorder. Journal of Clinical Psychopharmacology. 2001;21:335-339.

Awad R, Levac D, Cybulska P, Merali Z, Trudeau VL, Arnason JT. Effects of traditionally used anxiolytic botanicals on enzymes of the gamma-aminobutyric acid (GABA) system. Canadian Journal of Physiology and Pharmacology. 2007;85(9):933-942.
Brattstrom A. Scientific evidence for a fixed extract combination (Ze 91019) from valerian and hops traditionally used as a sleep-inducing aid. Wien Med Wochenschr. 2007;157(13-14):367-370.
Butterweck V, Brattstroem A, Grundmann O, Koetter U. Hypothermic effects of hops are antagonized with the competitive melatonin receptor antagonist luzindole in mice. The Journal of Pharmacy and Pharmacology. 2007;59:549-552.
Cauffield JS, Forbes HJ. Dietary supplements used in the treatment of depression, anxiety, and sleep disorders. Lippincotts Primary Care Practice. 1999;3(3):290-304.
Koetter U, Schrader E, Kaufeler R, Brattstrom A. A randomized, double blind, placebo-controlled, prospective clinical study to demonstrate clinical efficacy of a fixed valerian hops extract combination (Ze 91019) in patients suffering from non-organic sleep disorder. Phytotherapy Research. 2007;21(9):847-851.
Schiller H, Forster A, Vonhoff C, Hegger M, Biller A, Winterhoff H. Sedating effects of Humulus lupulus L. extracts. Phytomedicine. 2006;13(8):535-541.

headSTRONG is a dietary supplement designed to support normal brain function. It is not intended for use in the diagnosis or treatment of any disease. These statements have not been evaluated by the Food and Drug Administration. This product is a dietary supplement, not a drug, and is not intended to diagnose, mitigate, treat, cure or prevent any disease.
Placing an order indicates that you understand and agree to the Terms and Conditions of Sale.

Home Page | Success Stories | The Formula | FAQ's | About OCD | Site Map | Purchase